There are effective tactics to combat insulin resistance. Losing weight, exercising more or taking an insulin-sensitizing medication can help you get back to good blood glucose control and better health.
The pancreas pumps out more insulin to get blood sugar into cells. Over time, cells stop responding to all that insulin—they've become insulin resistant. The pancreas keeps making more insulin to try to make cells respond. Eventually, the pancreas can't keep up, and blood sugar keeps rising.